Pricing Table
Kit Size | Dosage per Vial | Total Peptide | Your Price | Price per U |
---|---|---|---|---|
10 Vials | 100U | 1000U | $550 | $0.55/U |
Quick Product Specs
- Purity: ≥99%
- Form: Lyophilized Powder
- Molecular Weight: ~150 kDa
- Storage: 2-8°C (refrigerated, never freeze)
- Shelf Life: 24 months unopened
What is Botulinum Toxin A?
Botulinum Toxin Type A is a potent neurotoxic protein produced by the bacterium Clostridium botulinum. It is one of seven distinct serotypes (A-G) and is the most extensively studied for therapeutic and research applications. The toxin consists of a heavy chain (100 kDa) and light chain (50 kDa) linked by a disulfide bond. Its mechanism involves highly specific binding to presynaptic cholinergic nerve terminals, internalization via receptor-mediated endocytosis, and proteolytic cleavage of SNAP-25 (synaptosomal-associated protein 25), a critical component of the SNARE complex required for acetylcholine vesicle fusion. This prevents neurotransmitter release, resulting in localized muscle paralysis lasting 3-6 months. The extraordinary specificity and reversibility make botulinum toxin invaluable for research into synaptic vesicle trafficking, neuromuscular junction physiology, SNARE protein function, and neuroplasticity.
Research Applications
- Neuromuscular junction physiology research
- SNARE complex and vesicle fusion studies
- Acetylcholine release mechanism research
- Presynaptic nerve terminal function studies
- Muscle physiology and denervation research
- Neuroplasticity and motor unit reorganization studies
- Autonomic nervous system and cholinergic signaling research
- Protein cleavage specificity (SNAP-25) studies